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 Prof. Jovana Petrovic University of Belgrade, Serbia |
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| 标题： Photonics-Assisted Smart Diagnostics of Heart Failure Jovana Petrovic, Vinca Institute of Nuclear Sciences, University of Belgrade, Serbia | |
| 摘要： Heart failure (HF), inability of heart to provide sufficient amount of blood for normal body function, is a serious condition associated with morbidity, mortality and high healthcare expenditures. Essential to the successful treatment of HF is its early detection. However, the conclusive diagnosis relies on a number of tests that are not accessible in the primary care. Therefore, huge efforts have been made to facilitate the timely diagnosis by the state-of-the-art sensing and decision-support technologies [1,2]. This requires application of multiparameter diagnostic tools that simultaneously assess electric and mechanical functions of cardiovascular system [3]. Stratification of such signals requires either a priori knowledge of the relevant biomarkers or a complex correlation analysis of large multiparamter data sets. Crucial in both cases are reliability and reproducibility of measurements. The prospects of application in primary healthcare impose further constraints on the diagnostic test, such as low cost and complexity, and short test duration. Here, I report on a polycardiographic diagnostic tool built by the SensSmart project consortium at the University of Belgrade. It enables non-invasive measurements of electro-mechanical processes of cardiovascular system: ECG, heart sounds, heart movement and arterial pulsations. Diagnostic information is deduced from the pulse forms. While the HF markers can be extracted as systolic time intervals between characteristic points of different signals, repeatability and reproducibility of their detection have been compromised by operator-dependence of the arterial pulse-wave point sensors. We show that these insufficiencies can be overcome by the fibre-grating sensing technology. In particular, high sensitivity and linearity make fibre grating sensors applicable by a non-specialist operator [4], while the edge filtering detection scheme allows for low-cost measurement [5]. We further explore strategies for dealing with the grating cross-sensitivity to the other body and environmental parameters. We leverage on the cross-sensitivity to respiration to develop a useful cardio-respiratory monitor [6]. Finally, I assess the prospects of application of fibre-optic and photoplethysmographic pulse wave sensors in clinical decision-support systems. I acknowledge funding from the Fund of Science of the Republic of Serbia, Grant SensSmart, No. 7754338. 1. V. Domazetoski, G. Gligoric et al. Comp. Meth. Prog. Biomed. 221 (2022) 106901 2. F. Yasmin, S.M.I. Shah et al. Rev. Cardiovasc. Med. 22 (2021) 1095 3. D. Mohebali and M.M. Kittleson. Heart 107 (2021) 366-372 4. M. D. Petrović, J. Petrovic et al. Phys. Scr. T157 (2013) 014022 5. M. D. Petrović, J. Petrovic et al. Biomed. Opt. Express 5 (2014) 1136 6. M. D. Ivanović, J. Petrovic et al. Physiol. Meas. 39 (2018) 045009 | |
| 简介： Dr Jovana Petrovic graduated from the School of Electronic Engineering, University of Belgrade, Serbia and earned her PhD from the Aston Institute of Photonic Technologies, Birmingham, UK. Upon postdoctoral research at the University of Oxford, UK and the Laboratory for Nonlinear Spectroscopy, Florence, Italy, and the tenured appointment at the Vinca Institute, Belgrade, Serbia, she joined the Centre for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany. She is appointed as an Associate Research Professor at the University of Belgrade. Dr. Petrovic has made a number of contributions to photonics, atomic and molecular physics. Her main scientific interests are in the areas of fibre-optic sensing, ultrafast lasers and laser cooling and control of atoms and molecules. Her research has resulted in 45 journal and 80 conference contributions and the foundation of a spin-off company. Dr. Petrovic serves as an expert project evaluator and monitor to the European Commission and is an active member of the Optical Society of America, Optical Society of Serbia and the German Physical Society. | |
