| 个人简介 | |
|---|---|
 Prof. Jianxin Chen Fujian Normal University, China |
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| 标题： Multiphoton diagnostic information and its application in in clinical medicine | |
| 摘要： Multiphoton microscopy uses ultrafast, near-infrared laser as excitation sources and bases on nonlinear optical signals of intrinsic fluorophores in tissues such as two or three photon-excited fluorescence (2PEF or 3PEF) and second or third harmonic generation (SHG or THG), providing enhanced imaging penetration depths in scattering samples, reduced overall specimen photodamage, photobleaching and phototoxicity. The first issue we need to answer is to establish the correlation between the tumor progression and optical diagnostic information when we want to translate it into routine clinical use of cancer diagnosis and therapy. In our research, we used ex vivo specimen of human oesophageal cancer, gastric cancer, colorectal cancer, cervical cancer, breast cancer, and brain tumor as the object of study to establish the correlation between the tumor progression and optical diagnostic information based on SHG and 2PEF. We demonstrated that MPM has the potential to differentiate between normal and dysplastic tissues, to differentiate between normal and cancerous tissues, to monitor cancer progression, to identify intramural metastasis, to detect morphological alterations in rectal cancer following preoperative radiochemotherapy to assess treatment efficacy in relation to dose or strategy and so on. | |
| 简介： Jianxin Chen received her Ph. D in 2002 from Harbin Institute of Technology (China) and completed postdoctoral studies from Peking University (China). She is Professor and Associate Dean of College of Photonic and Electronic Engineering, Fujian Normal University and Director of Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education. She was a Visiting Professor at Cornell University from 2014 to 2015. She also worked as a Visiting Professor at Yale University from 2010 to 2011. In 2008, she was a Visiting Scholar at BC Cancer Research Centre of Canada for half of year. She has authored or coauthored more than 150 papers in the international journals. Her research interests focus on application of multiphoton microscopy in the diagnosis and therapy of cancer. | |
